Molecular mechanisms regulating neural diversity
Molecular mechanisms regulating neural diversity
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Temporally expressed genes within neural progenitors not only define neuronal identity and connectivity, but also determine their ultimate function. We have recently identified more than a dozen transcription factors and RNA-binding proteins expressed temporally in neural stem cells. We will investigate how individual temporal factors determine neural/glial identity and function.
Temporally expressed genes within neural progenitors not only define neuronal identity and connectivity, but also determine their ultimate function. We have recently identified more than a dozen transcription factors and RNA-binding proteins expressed temporally in neural stem cells. We will investigate how individual temporal factors determine neural/glial identity and function.
Glial cell diversity and function
Glial cell diversity and function
Glial cells once thought to be just supporting cells outnumber neurons in our brain, yet we know very little about their development and function. Using the adult Drosophila brain as a model system, we will address glial differentiation and function.
Glial cells once thought to be just supporting cells outnumber neurons in our brain, yet we know very little about their development and function. Using the adult Drosophila brain as a model system, we will address glial differentiation and function.
Hormones and Brain development
Hormones and Brain development
Previously we have shown that steroid hormone ecdysone regulates temporal gene transitions, and neural diversity. However, the molecular mechanisms by which the hormonal signal exerts its function and changes the competency of neural stem cells remains to be elucidated.
Previously we have shown that steroid hormone ecdysone regulates temporal gene transitions, and neural diversity. However, the molecular mechanisms by which the hormonal signal exerts its function and changes the competency of neural stem cells remains to be elucidated.
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